A Unique Sequence Is Essential for Efficient Multidrug Efflux Function of the MtrD Protein of Neisseria gonorrhoeae-Reference-Cited by-同舟云学术

A Unique Sequence Is Essential for Efficient Multidrug Efflux Function of the MtrD Protein of Neisseria gonorrhoeae

Published:2021-08-31 Issue:4 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Chitsaz Mohsen¹^ORCID,Gupta Vrinda²,Harris Benjamin²,O’Mara Megan L.²^ORCID,Brown Melissa H.¹^ORCID

Affiliation:

1. College of Science and Engineering, Flinders University, Bedford Park, SA, Australia

2. Research School of Chemistry, Australian National University, Canberra, ACT, Australia

Abstract

The historical sexually transmitted infection gonorrhea continues to be a major public health concern with an estimated global annual incidence of 86.9 million cases. N. gonorrhoeae has been identified by the World Health Organization as one of the 12 antimicrobial-resistant bacterial species that poses the greatest risk to human health. As the major efflux pump in gonococci, the MtrD transporter contributes to the cell envelope barrier in this organism and pumps antimicrobials from the periplasm and inner membrane, resulting in resistance.

Funder

Flinders Medical Centre Foundation

National Computational Infrastructure

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01675-21

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