Neutralizing Activity of Broadly Neutralizing Anti-HIV-1 Antibodies against Primary African Isolates

Author:

Lorenzi Julio C. C.1,Mendoza Pilar1,Cohen Yehuda Z.1ORCID,Nogueira Lilian1,Lavine Christy2,Sapiente Joseph2,Wiatr Marie1,Mugo Nelly R.34,Mujugira Andrew5,Delany Sinead6,Lingappa Jairam478,Celum Connie479,Seaman Michael S.2,Caskey Marina1,Nussenzweig Michel C.110ORCID

Affiliation:

1. Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA

2. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA

3. Kenya Medical Research Institute, Nairobi, Kenya

4. Department of Global Health, University of Washington, Seattle, Washington, USA

5. Infectious Diseases Institute, Makerere University, Kampala, Uganda

6. University of the Witwatersrand, Johannesburg, South Africa

7. Department of Medicine, University of Washington, Seattle, Washington, USA

8. Department of Pediatrics, University of Washington, Seattle, Washington, USA

9. Department of Epidemiology, University of Washington, Seattle, Washington, USA

10. Howard Hughes Medical Institute, The Rockefeller University, New York, New York, USA

Abstract

HIV remains a major public health problem worldwide, and new therapies and preventive strategies are necessary for controlling the epidemic. Broadly neutralizing antibodies (bNAbs) have been developed in the past decade to fill this gap.

Funder

HHS | National Institutes of Health

Bill and Melinda Gates Foundation

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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