Affiliation:
1. Tuberculosis Research Centre, Chetput, Chennai 600 031, Tamil Nadu, India
Abstract
ABSTRACT
Mutations in the 81-bp rifampin resistance-determining region (RRDR) of the
rpoB
gene were analyzed by DNA sequencing of 50
Mycobacterium tuberculosis
clinical isolates (44 resistant and 6 sensitive) from various parts of India. Fifty-three mutations of 18 different kinds, 17 point mutations and one deletion, were observed in 43 of 44 resistant isolates. Three novel mutations and three new alleles within the RRDR, along with two novel mutations outside the RRDR, are reported in this study.
Publisher
American Society for Microbiology
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