Affiliation:
1. Unitat de Microbiologia Facultat de Medicina, Universitat Rovira i Virgili, Reus, Spain
Abstract
ABSTRACT
We have evaluated the efficacy of voriconazole (VRC) in a systemic infection by
Scedosporium apiospermum
in immunodepressed guinea pigs. Animals were infected with two strains; one required a VRC MIC of 0.5 to 1 μg/ml, common for this fungus, and the other required a high MIC (8 μg/ml), unusual in this species. VRC prolonged survival and reduced fungal load in kidney and brain tissues of the animals infected with the first strain but was unable to prolong survival or to reduce fungal load in brain tissue for the latter strain.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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