VanE-Type Vancomycin-Resistant Enterococcus faecalis Clinical Isolates from Australia

Author:

Abadía-Patiño Lorena1,Christiansen Keryn2,Bell Jan3,Courvalin Patrice1,Périchon Bruno1

Affiliation:

1. Unité des Agents Antibactériens, Institut Pasteur, Paris, France

2. Department of Microbiology and Infectious Diseases, Royal Perth Hospital, Perth, Western Australia

3. Women's and Children's Hospital, Adelaide, South Australia, Australia

Abstract

ABSTRACT Three distinct Enterococcus faecalis VanE-type isolates—BM4574, BM4575, and BM4576-obtained in Australia were studied. Expression of the resistance genes was constitutive in BM4575, probably due to a 2-bp deletion into the vanS E gene, and inducible in BM4574 and BM4576. Transcription analysis of the vanE operons suggested that the five genes were cotranscribed from an initiation site located 25 bp upstream from the ATG start codon of vanE .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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