Coproduction of KPC-18 and VIM-1 Carbapenemases by Enterobacter cloacae: Implications for Newer β-Lactam–β-Lactamase Inhibitor Combinations-Reference-Cited by-同舟云学术

Coproduction of KPC-18 and VIM-1 Carbapenemases by Enterobacter cloacae: Implications for Newer β-Lactam–β-Lactamase Inhibitor Combinations

Published:2016-03 Issue:3 Volume:54 Page:791-794
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Thomson Gina K.¹²,Snyder James W.²,McElheny Christi L.³,Thomson Kenneth S.²,Doi Yohei³

Affiliation:

1. Department of Microbiology, University of Louisville Hospital, Louisville, Kentucky, USA

2. Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, Kentucky, USA

3. Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

Abstract

ABSTRACT Enterobacter cloacae strain G6809 with reduced susceptibility to carbapenems was identified from a patient in a long-term acute care hospital in Kentucky. G6809 belonged to sequence type (ST) 88 and carried two carbapenemase genes, bla KPC-18 and bla VIM-1 . Whole-genome sequencing localized bla KPC-18 to the chromosome and bla VIM-1 to a 58-kb plasmid. The strain was highly resistant to ceftazidime-avibactam. Insidious coproduction of metallo-β-lactamase with KPC-type carbapenemase has implications for the use of next-generation β-lactam–β-lactamase inhibitor combinations.

Funder

Office of Extramural Research, National Institutes of Health

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.02739-15

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