Pharmacokinetics/Pharmacodynamics of Colistin and Imipenem on Mucoid and Nonmucoid Pseudomonas aeruginosa Biofilms-Reference-Cited by-同舟云学术

Pharmacokinetics/Pharmacodynamics of Colistin and Imipenem on Mucoid and Nonmucoid Pseudomonas aeruginosa Biofilms

Published:2011-09 Issue:9 Volume:55 Page:4469-4474
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Hengzhuang Wang¹,Wu Hong¹,Ciofu Oana²,Song Zhijun¹,Høiby Niels¹²³

Affiliation:

1. Department of Clinical Microbiology, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark

2. Institute for International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark

3. European Study Group for Biofilms (ESGB), European Society of Clinical Microbial and Infectious Diseases (ESCMID), Basel, Switzerland

Abstract

ABSTRACT The time course of activity of colistin and imipenem against mucoid and nonmucoid Pseudomonas aeruginosa growing in a biofilm showed that compared with those for planktonic bacteria, the kinetics of colistin and imipenem retained the concentration- and time-dependent killing, respectively, but higher doses of antibiotics and longer dosing periods were required for biofilm eradication. Biofilms of mucoid P. aeruginosa were more difficult to eradicate than nonmucoid biofilms.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00126-11

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