Enhancing Neuraminidase Immunogenicity of Influenza A Viruses by Rewiring RNA Packaging Signals-Reference-Cited by-同舟云学术

Enhancing Neuraminidase Immunogenicity of Influenza A Viruses by Rewiring RNA Packaging Signals

Published:2020-07-30 Issue:16 Volume:94 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Zheng Allen¹^ORCID,Sun Weina¹,Xiong Xiaoli²,Freyn Alec W.¹,Peukes Julia²,Strohmeier Shirin¹,Nachbagauer Raffael¹^ORCID,Briggs John A. G.²,Krammer Florian¹^ORCID,Palese Peter¹³

Affiliation:

1. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

2. Structural Studies Division, Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom

3. Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Abstract

Influenza virus infections are a major source of morbidity and mortality worldwide. Increasing evidence highlights neuraminidase as a potential vaccination target. This report demonstrates the efficacy of rewiring influenza virus packaging signals for creating vaccines with more neuraminidase content which provide better neuraminidase (NA)-based protection.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00742-20

Reference48 articles.

1. Shaw ML, Palese P. 2013. Orthomyxoviridae, p 1151–1185. In Knipe DM, Howley PM (ed), Fields virology, sixth edition. Lippincott Williams & Wilkins, Philadelphia, PA.

2. In the Shadow of Hemagglutinin: A Growing Interest in Influenza Viral Neuraminidase and Its Role as a Vaccine Antigen

3. Evaluation of Antihemagglutinin and Antineuraminidase Antibodies as Correlates of Protection in an Influenza A/H1N1 Virus Healthy Human Challenge Model

4. Next-generation influenza vaccines: opportunities and challenges

5. Antibody Correlates and Predictors of Immunity to Naturally Occurring Influenza in Humans and the Importance of Antibody to the Neuraminidase

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