Screening and Isolation of Penicillinase Inhibitor, KA-107-Reference-Cited by-同舟云学术

Screening and Isolation of Penicillinase Inhibitor, KA-107

Published:1973-09 Issue:3 Volume:4 Page:222-225
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Iwai Y.¹,Ohno H.¹,Takeshima H.¹,Yamaguchi N.¹,Ōmura S.¹,Hata T.¹

Affiliation:

1. The Kitasato Institute and Kitasato University, Minato-ku, Tokyo, Japan

Abstract

It is known that penicillin resistance of bacteria is mainly caused by the inactivation of penicillin by penicillinase derived from such strains. We have developed a screening procedure for penicillinase inhibitors. Several microorganisms were found to produce such inhibitors, and from the culture filtrate of Streptomyces gedanensis ATCC 4880 a penicillinase inhibitor, named KA-107, was isolated. The characteristics of this inhibitor were revealed by an in vitro test by using penicillinase derived from penicillin resistant Staphylococcus aureus , FS-1277. When KA-107 was used in combination with penicillin-G, ampicillin, d - or l -phenethicillin, the growth inhibitory activity of these penicillins was maintained.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.4.3.222

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