Affiliation:
1. Department of Microbiology, University of Western Australia, Perth Medical Centre, Shenton Park 6008, Western Australia
Abstract
BALB/c mice were exposed to fresh cigarette smoke, a mixture of SO
2
(5 ppm) and CO (50 ppm), or both for periods up to 18 weeks. After varying exposure times, animals were intratracheally inoculated with 10
8
sheep erythrocytes and sacrificed 7 days later, during which time the various exposure regimes were continued. Plaque-forming-cell responses were measured in spleens and a pool of the cervical and mediastinal lymph nodes, together with serum hemagglutinating and hemolytic responses, and compared with those of age-matched control animals. Both the organ and serum responses exhibited stimulation in the early phase of exposure, before a depression with prolonged exposure. The greatest depression was seen in animals that had been chronically exposed to both fresh cigarette smoke and the gas mixture.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference17 articles.
1. Berry G. M. L. Newhouse and M. Turok. 1972. Combined effects of asbestos exposure and smoking on mortality from Iung cancer in factory workers. Lancet ii:476-479.
2. Air pollution and cancer;Carnow B. W.;Arch. Environ. Health,1973
3. Further improvements in the plaque technique for detecting single antibody-forming cells;Cunningham A. J.;Immunology,1968
4. Cigarette smoking and haemagglutination inhibition response to influenza after natural disease and immunisation;Finklea J.;Amer. Rev. Resp. Dis.,1971
5. The ability of human serum to agglutinate sheep erythrocytes and the effect of tobacco mosaic virus;Fletcher R. D.;Amer. Rev. Resp. Dis.,1969
Cited by
12 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献