New World Monkey Aotus nancymae as a Model for Campylobacter jejuni Infection and Immunity-Reference-Cited by-同舟云学术

New World Monkey Aotus nancymae as a Model for Campylobacter jejuni Infection and Immunity

Published:2006-01 Issue:1 Volume:74 Page:790-793
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Jones Franca R.¹,Baqar Shahida²,Gozalo Alfonso¹,Nunez Gladys¹,Espinoza Nereyda¹,Reyes Sharina M.²,Salazar Milagros¹,Meza Rina¹,Porter Chad K.²,Walz Stephen E.¹

Affiliation:

1. Bacterial Diseases Program, Naval Medical Research Center Detachment (NMRCD—Lima, Peru), NMRCD Unit 3800, APO, AA 34031

2. Enteric Diseases Department, Naval Medical Research Center (NMRC), 503 Robert Grant Avenue, Silver Spring, Maryland 20910

Abstract

ABSTRACT Three groups of six monkeys ( Aotus nancymae ) each were inoculated intragastrically with increasing doses of Campylobacter jejuni . Infection resulted in fecal colonization (100% of monkeys), dose-related diarrhea, and robust immune responses. Colonization duration and diarrhea rate were reduced upon secondary challenge. A. nancymae may be useful for studying anti- Campylobacter vaccine efficacy.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.74.1.790-793.2006

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