<i>Toxoplasma</i>Shelph, a Phosphatase Located in the Parasite Endoplasmic Reticulum, Is Required for Parasite Virulence-Reference-Cited by-同舟云学术

ToxoplasmaShelph, a Phosphatase Located in the Parasite Endoplasmic Reticulum, Is Required for Parasite Virulence

Published:2022-12-21 Issue:6 Volume:7 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Najm Rania¹²,Hamie Maguy³,Berry-Sterkers Laurence²,Lebrun Maryse²,El Hajj Hiba³,Lamarque Mauld H.²^ORCID

Affiliation:

1. Department of Biomedical Sciences, College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates

2. LPHI, UMR 5235 CNRS, Université de Montpellier, Montpellier, France

3. Department of Experimental Pathology, Immunology and Microbiology, American University of Beirut, Beirut, Lebanon

Abstract

Toxoplasma gondiibelongs to theApicomplexaphylum, which comprises more than 5,000 species, among which isPlasmodium falciparum, the notorious agent of human malaria. Intriguingly, theApicomplexagenomes encode at least one phosphatase closely related to the bacterialSchewanellaphosphatase, or Shelph.

Funder

Laboratoire d'Excellence Parafrap

Agence Nationale de la Recherche

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00350-22

Reference81 articles.

1. The history and life cycle of Toxoplasma gondii

2. Pathophysiology of toxoplasmosis

3. Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine;Gazzinelli RT;J Immunol,1991

4. Effector Cells of Both Nonhemopoietic and Hemopoietic Origin Are Required for Interferon (IFN)-γ– and Tumor Necrosis Factor (TNF)-α–dependent Host Resistance to the Intracellular Pathogen, Toxoplasma gondii

5. Toxoplasmic Encephalitis in AIDS