Efficient Gene Knockout and Knockdown Systems in Neospora caninum Enable Rapid Discovery and Functional Assessment of Novel Proteins-Reference-Cited by-同舟云学术

Efficient Gene Knockout and Knockdown Systems in Neospora caninum Enable Rapid Discovery and Functional Assessment of Novel Proteins

Published:2022-02-23 Issue:1 Volume:7 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Mineo Tiago W. P.¹²^ORCID,Chern Jessica H.¹,Thind Amara C.¹³,Mota Caroline M.¹²,Nadipuram Santhosh M.¹,Torres Juan A.¹,Bradley Peter J.¹³^ORCID

Affiliation:

1. Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA

2. Laboratory of Immunoparasitology “Dr. Mário Endsfeldz Camargo,” Institute of Biomedical Sciences, Universidade Federal de Uberlândia, Uberlândia, Minas Gerais, Brazil

3. Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California, USA

Abstract

Neospora caninum is a parasite with veterinary relevance, inducing severe disease in dogs and reproductive disorders in ruminants, especially cattle, leading to major losses. The close phylogenetic relationship to Toxoplasma gondii and the lack of pathogenicity in humans drives an interest of the scientific community toward using N. caninum as a model to study the pathogenicity of T. gondii .

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação de Amparo à Pesquisa do Estado de Minas Gerais

HHS | National Institutes of Health

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00896-21

Reference56 articles.