A Translational Pharmacokinetic Rat Model of Cerebral Spinal Fluid and Plasma Concentrations of Cefepime-Reference-Cited by-同舟云学术

A Translational Pharmacokinetic Rat Model of Cerebral Spinal Fluid and Plasma Concentrations of Cefepime

Published:2019-02-27 Issue:1 Volume:4 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Avedissian Sean N.¹²^ORCID,Pais Gwendolyn¹²,Joshi Medha D.²³^ORCID,Rhodes Nathaniel J.¹²^ORCID,Scheetz Marc H.¹²⁴^ORCID

Affiliation:

1. Department of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA

2. Center of Pharmacometric Excellence, Midwestern University, Downers Grove, Illinois, USA

3. Department of Pharmaceutical Sciences, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA

4. College of Graduate Studies, Department of Pharmacology, Midwestern University, Downers Grove, Illinois, USA

Abstract

This study defines the transit of cefepime between plasma and cerebral spinal fluid (CSF) in a rat model. Male Sprague-Dawley rats received cefepime intravenously. Plasma samples were obtained via a second dedicated intravenous catheter. CSF sampling occurred via an intracisternal catheter. Drug exposures and transfer from the plasma to the CSF during the first 24 h were calculated. The median CSF/blood percentage of penetration was 19%. Cefepime transit to the CSF is rapid and predictable in the rat model. This model will be highly useful for understanding the therapeutic window for cefepime and neurotoxicity.

Funder

Midwestern University Chicago College of Pharmacy

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00595-18

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