In-Human Multiyear Evolution of Carbapenem-Resistant Klebsiella pneumoniae Causing Chronic Colonization and Intermittent Urinary Tract Infections: A Case Study

Author:

Kalu Michelle1ORCID,Tan Karen1,Algorri Marquerita1,Jorth Peter234ORCID,Wong-Beringer Annie15ORCID

Affiliation:

1. University of Southern California, School of Pharmacy, Los Angeles, California, USA

2. Cedars-Sinai Medical Center, Department of Pathology and Laboratory Medicine, Los Angeles, California, USA

3. Cedars-Sinai Medical Center, Department of Medicine, Los Angeles, California, USA

4. Cedars-Sinai Medical Center, Department of Biomedical Sciences, Los Angeles, California, USA

5. Huntington Memorial Hospital, Department of Pharmacy Services, Pasadena, California, USA

Abstract

Carbapenem-resistant Klebsiella pneumoniae (CRKP) can cause a variety of infections such as recurrent urinary tract infections (rUTI) with the ability to change with the host environment over time. However, it is unclear how CRKP adapts to the urinary tract during chronic infections and colonization.

Funder

American Foundation for Pharmaceutical Education

Merck

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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