Post-COVID mRNA-vaccine IgG4 shift: worrisome?-Reference-Cited by-同舟云学术

Post-COVID mRNA-vaccine IgG4 shift: worrisome?

Published:2023-08-24 Issue:4 Volume:8 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Kadkhoda Kamran¹²

Affiliation:

1. Immunopathology Laboratory, Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic , Cleveland, Ohio, USA

2. Cleveland Clinic Lerner College of Medicine, Case Western Reserve University , Cleveland, Ohio, USA

Abstract

ABSTRACT COVID-19 vaccines play a key role in ending the pandemic. Unraveling the immunological phenomena involved in offering protective immunity is the cornerstone of achieving such success. This perspective evaluates the possible mechanisms and implications of IgG4 production in response to mRNA-based COVID-19 vaccines.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00085-23

Reference15 articles.

1. mRNA vaccines against SARS-CoV-2 induce comparably low long-term IgG Fc galactosylation and sialylation levels but increasing long-term IgG4 responses compared to an adenovirus-based vaccine

2. Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination

3. Distinguishing features of current COVID-19 vaccines: knowns and unknowns of antigen presentation and modes of action

4. Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis

5. Follicular B2 Cell Activation and Class Switch Recombination Depend on Autocrine C3ar1/C5ar1 Signaling in B2 Cells

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