Role of RpoS in Regulating Stationary Phase Salmonella Typhimurium Pathogenesis-Related Stress Responses under Physiological Low Fluid Shear Force Conditions

Author:

Franco Meléndez Karla123,Crenshaw Keith12,Barrila Jennifer13,Yang Jiseon13,Gangaraju Sandhya3,Davis Richard R.13,Forsyth Rebecca J.13,Ott C. Mark4,Kader Rebin1,Curtiss Roy1,Roland Kenneth3,Nickerson Cheryl A.123ORCID

Affiliation:

1. Center for Infectious Diseases and Vaccinology, the Biodesign Institute, Arizona State University, Tempe, Arizona, USA

2. School of Life Sciences, Arizona State University, Tempe, Arizona, USA

3. Biodesign Center for Fundamental and Applied Microbiomics, Arizona State University, Tempe, Arizona, USA

4. Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, Texas, USA

Abstract

Bacterial pathogens respond dynamically to a variety of stresses in the infected host, including physical forces of fluid flow (fluid shear) across their surfaces. While pathogens experience wide fluctuations in fluid shear during infection, little is known about how these forces regulate microbial pathogenesis.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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