Specific Norovirus Interaction with Lewis x and Lewis a on Human Intestinal Inflammatory Mucosa during Refractory Inflammatory Bowel Disease

Author:

Tarris Georges1,de Rougemont Alexis23ORCID,Estienney Marie23,Charkaoui Maeva4,Mouillot Thomas4,Bonnotte Bernard56,Michiels Christophe4,Martin Laurent16,Belliot Gaël23ORCID

Affiliation:

1. Department of Pathology, University Hospital of Dijon, Dijon, France

2. National Reference Centre for Gastroenteritis Viruses, Laboratory of Virology, University Hospital of Dijon, Dijon, France

3. UMR PAM A 02.102 Procédés Alimentaires et Microbiologiques, Université de Bourgogne Franche-Comté/AgroSup Dijon, Dijon, France

4. Department of Gastroenterology and Hepatology, University Hospital of Dijon, Dijon, France

5. Department of Internal Medicine and Clinical Immunology, University Hospital of Dijon, Dijon, France

6. Univ. Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098, Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique, Dijon, France

Abstract

Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), are progressive diseases affecting millions of people each year. Flare-ups during IBD result in severe mucosal alterations of the small intestine (in CD) and in the colon and rectum (in CD and UC).

Funder

European Regional Development Fund

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference51 articles.

1. The burden of inflammatory bowel disease in Europe

2. Fenoglio-Preiser CM, Noffsinger AE, Stemmermann GN, Lantz PE, Isaacson PG. 2008. Gastrointestinal pathology, 3rd ed, p 593–690. Lippincott Williams & Wilkins, Philadelphia, PA.

3. The gut microbiota in IBD

4. The role of glycosylation in IBD

5. Comparative study of the intestinal mucus barrier in normal and inflamed colon

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