HPV-18E6 Inhibits Interactions between TANC2 and SNX27 in a PBM-Dependent Manner and Promotes Increased Cell Proliferation-Reference-Cited by-同舟云学术

HPV-18E6 Inhibits Interactions between TANC2 and SNX27 in a PBM-Dependent Manner and Promotes Increased Cell Proliferation

Published:2022-11-23 Issue:22 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Broniarczyk Justyna Karolina¹²^ORCID,Massimi Paola¹,Trejo-Cerro Oscar¹,Myers Michael P.¹,Banks Lawrence¹^ORCID

Affiliation:

1. International Centre for Genetic Engineering and Biotechnology, Padriciano, Trieste, Italy

2. Department of Molecular Virology, Adam Mickiewicz University, Uniwersytetu Poznanskiego, Poznan, Poland

Abstract

While a great deal is known about the role of the E6 PDZ binding motif (PBM) in modulating the cellular proteins involved in regulating cell polarity, much less is known about the consequences of E6's interactions with SNX27 and the endocytic sorting machinery. We reasoned that a potential consequence of such interactions could be to affect the fate of multiple SNX27 endosomal partners, such as transmembrane proteins or soluble accessory proteins.

Funder

Associazione Italiana per la Ricerca sul Cancro

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01365-22

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