Affiliation:
1. Jewish General Hospital, Montreal, Quebec, Canada.
Abstract
We have shown that the spermicidal agent benzalkonium chloride can exert a direct inhibitory effect on the viral reverse transcriptase activity of human immunodeficiency virus type 1 (HIV-1) when utilized at concentrations of 0.05% and higher. Exposure of HIV-1 to this disinfectant at concentrations of more than 0.05% was able to completely destroy viral infectivity, as assessed on susceptible target cells. We have further shown that HIV-1, which is present in both seminal and genital secretions, can be inactivated in such fluids by direct exposure to benzalkonium chloride.
Publisher
American Society for Microbiology
Reference11 articles.
1. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS);Barre-Sinoussi F.;Science,1983
2. Separation of leukocytes from blood and bone marrow;Boyum A.;Scand. J. Clin. Lab. Invest.,1968
3. Antimicrobial activity and physico-chemical properties of some alkyldimethylbenzylammonium chlorides;Daoud N. N.;Microbios,1983
4. Favero M. S. 1983. Chemical disinfection of medical and surgical materials p. 469-492. In S. S. Block (ed.) Disinfection sterilization and preservation 3rd ed. Lea & Febiger Philadelphia.
5. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS;Gallo R. C.;Science,1984
Cited by
36 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献