Increased Resistance to Taenia crassiceps Murine Cysticercosis in Qa-2 Transgenic Mice-Reference-Cited by-同舟云学术

Increased Resistance to Taenia crassiceps Murine Cysticercosis in Qa-2 Transgenic Mice

Published:1998-02 Issue:2 Volume:66 Page:760-764
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Fragoso Gladis¹,Lamoyi Edmundo¹,Mellor Andrew²,Lomelí Ciro¹,Hernández Marisela¹,Sciutto Edda¹

Affiliation:

1. Department of Immunology, Instituto de Investigaciones Biomédicas, UNAM, México D.F. 04510, México,1 and

2. Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 309122

Abstract

ABSTRACT We previously reported important differences in resistance to Taenia crassiceps murine cysticercosis between BALB/c substrains. It was suggested that resistance might correlate with expression of the nonclassic class I major histocompatibility complex (MHC) Qa-2 antigen; BALB/cAnN is Qa-2 negative and highly susceptible to T. crassiceps , whereas BALB/cJ expresses Qa-2 and is highly resistant. In this study, we investigated the role of Qa-2 in mediating resistance to cysticercosis by linkage analysis and infection of Qa-2 transgenic mice. In BALB/cAnN × (C57BL/6J × BALB/cAnN)F 1 and BALB/cAnN × (BALB/cJ × BALB/cAnN)F 1 backcrosses, the expression of Qa-2 antigen correlated with resistance to cysticercosis. Significantly fewer parasites were recovered from infected Qa-2 transgenic male and female mice than from nontransgenic mice of similar genetic background. These results clearly demonstrate that the Qa-2 MHC antigen is involved in resistance to T. crassiceps cysticercosis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.66.2.760-764.1998

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