Defective Flux of Thrombospondin-4 through the Secretory Pathway Impairs Cardiomyocyte Membrane Stability and Causes Cardiomyopathy-Reference-Cited by-同舟云学术

Defective Flux of Thrombospondin-4 through the Secretory Pathway Impairs Cardiomyocyte Membrane Stability and Causes Cardiomyopathy

Published:2018-07-15 Issue:14 Volume:38 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Brody Matthew J.¹,Vanhoutte Davy¹,Schips Tobias G.¹,Boyer Justin G.¹²,Bakshi Chinmay V.¹,Sargent Michelle A.¹²,York Allen J.¹²,Molkentin Jeffery D.¹²

Affiliation:

1. Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA

2. Howard Hughes Medical Institute, Cincinnati, Ohio, USA

Abstract

Thrombospondins are stress-inducible secreted glycoproteins with critical functions in tissue injury and healing. Thrombospondin-4 (Thbs4) is protective in cardiac and skeletal muscle, where it activates an adaptive endoplasmic reticulum (ER) stress response, induces expansion of the ER, and enhances sarcolemmal stability.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00114-18

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