Affiliation:
1. Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30303
Abstract
Antagonism, determined by isobolograms constructed from data from combinations of ampicillin and chloramphenicol at or below the minimal inhibitory or bactericidal concentrations, was observed against 13 clinical isolates of meningococcus and against one isolate of pneumococcus. Synergy occurred against six strains of pneumococcus and three of meningococcus. Additive effects were noted against 14 isolates of pneumococcus and 5 of meningococcus. There was no relationship between the minimal inhibitory or bactericidal concentrations for the isolates and the occurrence of antagonistic, additive, or synergistic effects. These data indicate that ampicillin and chloramphenicol may be antagonistic in vitro against some strains of pneumococcus or meningococcus.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference9 articles.
1. Studies of combinations of antibiotics in vitro and in experimental infections in mice;Bliss E. A.;Bull. Johns Hopkins Hosp.,1952
2. Ampicillinresistant strains of Haemophilus influenzae type b;Committee on Infectious Diseases.;Pediatrics,1974
3. In vitro effects of carbenicillin combined with gentamicin or polymyxin B against Pseudomonas aeruginosa;Eickhoff T. C.;Appl. Microbiol.,1969
4. Antagonists of nucleic acid derivatives. III. Synergism in combinations of biochemically related antibiotics;Elion G. B.;J. Biol. Chem.,1954
5. Concentrations of bacteria in cerebrospinal fluid of patients with bacterial meningitis;Feldman W. E.;J. Pediatr.,1976
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