Affiliation:
1. Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
Abstract
Chlamydia
is an obligate intracellular pathogen with a highly reduced genome devoid of major stress response genes like
relA
and
spoT
, which mediate the stringent response. Interestingly, as an intracellular bacterium dependent on its host for nutrients and as a tryptophan (Trp) auxotroph,
Chlamydia
is very sensitive to Trp starvation, which is induced
in vivo
by the host cytokine interferon-γ.
Funder
HHS | National Institutes of Health
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
1 articles.
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