Dynamics of bla KPC-2 Dissemination from Non-CG258 Klebsiella pneumoniae to Other Enterobacterales via IncN Plasmids in an Area of High Endemicity-Reference-Cited by-同舟云学术

Dynamics of bla KPC-2 Dissemination from Non-CG258 Klebsiella pneumoniae to Other Enterobacterales via IncN Plasmids in an Area of High Endemicity

Published:2020-11-17 Issue:12 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Rada Ana M.¹²^ORCID,De La Cadena Elsa³,Agudelo Carlos⁴,Capataz Cesar⁵,Orozco Nataly¹,Pallares Cristian³,Dinh An Q.⁶,Panesso Diana⁶⁷,Ríos Rafael⁶⁷,Diaz Lorena⁶⁷,Correa Adriana⁸,Hanson Blake M.⁶,Villegas Maria V.³,Arias Cesar A.⁶⁷⁹,Restrepo Eliana¹

Affiliation:

1. Department of Microbiology and Parasitology, Bacteria and Cancer Group, Universidad de Antioquia, Medellín, Colombia

2. Faculad de Ciencias de la Salud, Biociencias Group, Institución Universitaria Colegio Mayor de Antioquia, Medellín, Colombia

3. Research Group on Antimicrobial Resistance and Hospital Epidemiology, Universidad El Bosque, Bogotá, Colombia

4. Clinica Universitaria Bolivariana, School of Health Sciences, Universidad Pontificia Bolivariana, Medellín, Colombia

5. Fundación Clínica del Norte, Bello, Colombia

6. Division of infectious Diseases and Center for Antimicrobial Resistance and Microbial Genomics, UTHealth, McGovern Medical School, Houston, Texas, USA

7. Molecular Genetics and Antimicrobial Resistance Unit–International Center for Microbial Genomics, Universidad El Bosque, Bogotá, Colombia

8. Universidad Santiago de Cali, Facultad de Ciencias Básicas, Cali, Colombia

9. Center for Infectious Diseases, UTHealth, School of Public Health, Houston, Texas, USA

Abstract

Carbapenem-resistant Enterobacterales (CRE) pose a significant threat to global public health. The most important mechanism for carbapenem resistance is the production of carbapenemases. Klebsiella pneumoniae carbapenemase (KPC) represents one of the main carbapenemases worldwide. Complex mechanisms of bla KPC dissemination have been reported in Colombia, a country with a high endemicity of carbapenem resistance. Here, we characterized the dynamics of dissemination of bla KPC gene among CRE infecting and colonizing patients in three hospitals localized in a highly endemic area of Colombia (2013 and 2015).

Funder

Institución Universitaria Colegio Mayor de Antioquia

HHS | NIH | National Institute of Allergy and Infectious Diseases

Departamento Administrativo de Ciencia, Tecnología e Innovación

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01743-20

Reference53 articles.

1. The Epidemiology of Carbapenem-Resistant Enterobacteriaceae: The Impact and Evolution of a Global Menace