Model-Based Exposure-Response Assessment for Spectinamide 1810 in a Mouse Model of Tuberculosis-Reference-Cited by-同舟云学术

Model-Based Exposure-Response Assessment for Spectinamide 1810 in a Mouse Model of Tuberculosis

Published:2021-10-18 Issue:11 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wagh Santosh¹,Rathi Chetan¹,Lukka Pradeep B.¹^ORCID,Parmar Keyur¹,Temrikar Zaid¹,Liu Jiuyu²,Scherman Michael S.³,Lee Richard E.²,Robertson Gregory T.³^ORCID,Lenaerts Anne J.³,Meibohm Bernd¹^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA

2. Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA

3. Mycobacterial Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA

Abstract

Despite decades of research, tuberculosis remains a leading cause of death from a single infectious agent. Spectinamides are a promising novel class of antituberculosis agents, and the lead spectinamide 1810 has demonstrated excellent efficacy, safety, and drug-like properties in numerous in vitro and in vivo assessments in mouse models of tuberculosis.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

American Lebanese Syrian Associated Charities

HHS | NIH | NIH Office of the Director

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01744-20

Reference59 articles.

1. Tuberculosis