2′-Fluoro-2′-Deoxycytidine Inhibits Borna Disease Virus Replication and Spread

Author:

Bajramovic Jeffrey J.1,Volmer Romain1,Syan Sylvie1,Pochet Sylvie2,Gonzalez-Dunia Daniel13

Affiliation:

1. Unité des Virus Lents, CNRS URA 1930

2. Unité de Chimie Organique, CNRS URA 2128, Institut Pasteur, Paris

3. INSERM U563, CPTP, Toulouse, France

Abstract

ABSTRACT Borna disease virus (BDV) causes neurological diseases in a variety of warm-blooded animal species, possibly including humans. To date, there is no effective treatment against BDV infection. Recently, we reported on the antiviral activity of 1-β- d -arabinofuranosylcytosine (Ara-C). However, Ara-C's cytotoxic side effects are a major obstacle for its therapeutic use. Herein, we demonstrate that the nucleoside analog 2′-fluoro-2′-deoxycytidine (2′-FdC) exhibits potent antiviral activity against BDV. Importantly, 2′-FdC-associated cytotoxicity is negligible, indicating 2′-FdC as an excellent candidate for the development of antiviral therapy against BDV.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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