Stress Response in Entamoeba histolytica Is Associated with Robust Processing of tRNA to tRNA Halves-Reference-Cited by-同舟云学术

Stress Response in Entamoeba histolytica Is Associated with Robust Processing of tRNA to tRNA Halves

Published:2023-04-25 Issue:2 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Sharma Manu¹,Zhang Hanbang¹,Ehrenkaufer Gretchen¹,Singh Upinder¹²^ORCID

Affiliation:

1. Division of Infectious Diseases, Stanford University School of Medicine, Stanford, California, USA

2. Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA

Abstract

In the present study, we report for the first time the presence of tRNA-derived fragments in Entamoeba . tRNA-derived fragments were identified by bioinformatics analyses of small-RNA sequencing data sets from the parasites and also confirmed experimentally. We found that tRNA halves accumulated in parasites exposed to environmental stress or during the developmental process of encystation.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03450-22

Reference64 articles.

1. Pathophysiology of amoebiasis

2. Encystation in parasitic protozoa

3. Characterization of Extracellular Vesicles from Entamoeba histolytica Identifies Roles in Intercellular Communication That Regulates Parasite Growth and Development