Evidence for Multiple Subpopulations of Herpesvirus-Latently Infected Cells-Reference-Cited by-同舟云学术

Evidence for Multiple Subpopulations of Herpesvirus-Latently Infected Cells

Published:2022-02-22 Issue:1 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Landis Justin T.¹,Tuck Ryan¹,Pan Yue²,Mosso Carson N.³,Eason Anthony B.¹,Moorad Razia¹,Marron J. Stephen²³,Dittmer Dirk P.¹^ORCID

Affiliation:

1. Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

2. Department of Biostatistics, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

3. Department of Statistics and Operations Research, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

Abstract

Latency is the defining characteristic of the Herpesviridae and central to the tumorigenesis phenotype of Kaposi’s sarcoma-associated herpesvirus (KSHV). KSHV-driven primary effusion lymphomas (PEL) rapidly develop resistance to therapy, suggesting tumor instability and plasticity.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03473-21

Reference123 articles.

1. Epigenetic diversity of Kaposi’s sarcoma–associated herpesvirus

2. The Epigenetic Landscape of Latent Kaposi Sarcoma-Associated Herpesvirus Genomes

3. The Open Chromatin Landscape of Kaposi's Sarcoma-Associated Herpesvirus