Internalization of HIV-1 by Phagocytes Is Increased When Virions Are Opsonized with Multimeric Antibody in the Presence of Complement-Reference-Cited by-同舟云学术

Internalization of HIV-1 by Phagocytes Is Increased When Virions Are Opsonized with Multimeric Antibody in the Presence of Complement

Published:2022-01-26 Issue:2 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Gach Johannes S.¹^ORCID,Matsuno Stephanie Y.¹,Mercado Mayalen¹,Hangartner Lars²,Forthal Donald N.¹³^ORCID

Affiliation:

1. Department of Medicine, Division of Infectious Diseases, University of California, Irvine School of Medicine, Irvine, California, USA

2. Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA

3. Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California, USA

Abstract

Antibody-mediated internalization of HIV-1 by phagocytes, a potential mechanism for clearing virus, is very inefficient. In an effort to improve viral clearance, we produced a multimeric form of the broadly neutralizing monoclonal antibody VRC01.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01689-21

Reference31 articles.

1. Antiviral Functions of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific IgG Antibodies: Effects of Antiretroviral Therapy and Implications for Therapeutic HIV-1 Vaccine Design

2. Functions of Antibodies

3. Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge

4. Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys

5. Immune correlates of vaccine protection against HIV-1 acquisition

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Virion-surface display of a chimeric immunoglobulin Fc domain facilitating uptake by antigen-presenting cells;Journal of Biotechnology;2024-08

2. Neutralizing the threat: harnessing broadly neutralizing antibodies against HIV-1 for treatment and prevention;MICROB CELL;2024

3. Polyfunctionality of broadly neutralizing HIV-1 antibodies;Current Opinion in HIV and AIDS;2023-05-09