Affiliation:
1. Department of Pharmacology, University of Texas Southwestern Medical School, Dallas, Texas 75235
Abstract
Experiments were conducted to examine the effects of certain aminoglycoside antibiotics on contractile responses and related calcium ion (Ca
2+
) movements in isolated vascular smooth muscle. Gentamicin, kanamycin, and streptomycin decreased contractile responses produced by norepinephrine, histamine, and high K
+
in rabbit aortic strips. The inhibitory action of these antibiotics on mechanical function was more pronounced when the Ca
2+
concentration of the bathing solution was decreased from 1.5 mM (normal Ca
2+
solution) to 0.05 mM (low Ca
2+
solution). The uptake of radiocalcium (
45
Ca) into the isolated media-intimal layer of rabbit aortae was decreased in a maintained manner by each antibiotic. With gentamicin, the inhibitory effect on
45
Ca uptake was shown to be dependent upon the concentration of gentamicin employed and to be more evident in a 0.1 mM Ca
2+
solution than in a normal Ca
2+
solution. In addition, the rate of
45
Ca efflux from the rabbit aortic media-intimal layer was increased in a sustained manner by gentamicin, streptomycin, and kanamycin. Furthermore, contractile responses induced by high K
+
and norepinephrine in canine carotid arterial strips were inhibited by gentamicin. Present findings indicate that aminoglycoside antibiotics interfere with Ca
2+
-linked events leading to activation of the contractile mechanism of vascular smooth muscle. These in vitro findings may partially explain the occurrence of in vivo cardiovascular depression that has occasionally been observed after the administration of chemically related antimicrobial agents.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference30 articles.
1. Effects of neomycin on tension and "Ca movements in rabbit aortic smooth muscle;Adams H. R.;Life Sci.,1973
2. Effect of EDTA and SCN on radiocalcium movement in frog rectus abdominis muscle during contractures induced by calcium removal;Bianchi C. P.;J. Pharmacol. Exp. Ther.,1965
3. Depression of cardiac function by streptomycin and other antimicrobial agents;Cohen L. S.;Amer. J. Cardiol.,1970
4. Ganglioplegic action of streptomycin;Corrado A. P.;Arch. Int. Pharmacodyn. Ther.,1958
5. Neomycin-its curariform and ganglioplegic actions;Corrado A. P.;Rev. Brasil. Biol.,1958
Cited by
30 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献