Epstein-Barr Virus and Human Herpesvirus 6 Detection in a Non-Hodgkin's Diffuse Large B-Cell Lymphoma Cohort by Using RNA Sequencing-Reference-Cited by-同舟云学术

Epstein-Barr Virus and Human Herpesvirus 6 Detection in a Non-Hodgkin's Diffuse Large B-Cell Lymphoma Cohort by Using RNA Sequencing

Published:2013-12 Issue:23 Volume:87 Page:13059-13062
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Strong Michael J.¹²,O'Grady Tina¹²,Lin Zhen¹²,Xu Guorong³,Baddoo Melody¹²,Parsons Chris⁴,Zhang Kun⁵,Taylor Christopher M.⁴⁶,Flemington Erik K.¹²

Affiliation:

1. Department of Pathology, Tulane University, New Orleans, Louisiana, USA

2. Tulane Cancer Center, New Orleans, Louisiana, USA

3. Baylor Institute for Immunology Research, Dallas, Texas, USA

4. Department of Microbiology, Immunology & Parasitology, Louisiana State University School of Medicine, New Orleans, Louisiana, USA

5. Department of Computer Science, Xavier University of Louisiana, New Orleans, Louisiana, USA

6. Research Institute for Children, Children's Hospital, New Orleans, Louisiana, USA

Abstract

ABSTRACT Comprehensive virome analysis of RNA sequence (RNA-seq) data sets from 118 non-Hodgkin's B-cell lymphomas revealed a small subset that is positive for Epstein-Barr virus (EBV) or human herpesvirus 6B (HHV-6B), with one coinfection. EBV transcriptome analysis revealed expression of the latency genes RPMS1, LMP1, and LMP2, with one sample additionally showing a high level of early lytic expression and another sample showing a high level of EBNA2 expression. HHV-6B transcriptome analysis revealed that the majority of genes were transcribed.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02380-13

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