Susceptibility of Anaerobic Bacteria to Carbenicillin

Author:

Blazevic Donna J.1,Matsen John M.1

Affiliation:

1. Departments of Laboratory Medicine and Pathology, Pediatrics, and Microbiology, University of Minnesota, Minneapolis, Minnesota 55455

Abstract

One hundred and seventy-one strains of anaerobes were tested for susceptibility to carbenicillin by using agar dilution, broth dilution, and two disk diffusion methods. The minimal inhibitory concentration (MIC) for 67% of 51 strains of Bacteroides fragilis , 7 of 9 strains of Bacteroides melaninogenicus , and all of 8 strains of Eubacterium was 100 μg or less per ml. The MICs of the remaining anaerobes were 50 μg or less per ml. The broth dilution results were felt to be the most accurate of the four methods utilized.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference8 articles.

1. Antibiotic sensitivity testing. Report of an international collaborative study;Ericsson H. M.;Acta Pathol. Microbiol. Scand. (Suppl.),1971

2. Holdeman L. V. and W. E. C. Moore. 1972. Anaerobe laboratory manual. Virginia Polytechnic Institute Anaerobe Laboratory Blacksburg Va.

3. The susceptibility of Bacteroides fragilis to 24 antibiotics;Kislak J. W.;J. Infect. Dis.,1972

4. In vitro antimicrobial susceptibility of anaerobic bacteria isolated from clinical specimens;Martin W. J.;Antimicrob. Ag. Chemother.,1972

5. Carbenicillin therapy of severe Pseudomonas aeruginosa infections;Solberg C. O.;J. Chronic Dis.,1971

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