The Denture-Associated Oral Microbiome in Health and Stomatitis

Author:

Shi Baochen1,Wu Tingxi2,McLean Jeffrey3,Edlund Anna24,Young Youngik4,He Xuesong2,Lv Hongyang5,Zhou Xuedong5,Shi Wenyuan2,Li Huiying1,Lux Renate2

Affiliation:

1. Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of Los Angeles at Los Angeles, Los Angeles, California, USA

2. School of Dentistry, University of Los Angeles at Los Angeles, Los Angeles, California, USA

3. Department of Periodontics, School of Dentistry, University of Washington, Seattle, Washington, USA

4. Microbial and Environmental Genomics, J. Craig Venter Institute, La Jolla, California, USA

5. West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China

Abstract

Denture stomatitis is a prevalent inflammatory condition of the mucosal tissue in denture wearers that is triggered by microorganisms. While Candida has been extensively studied for its role in stomatitis etiology, the bacterial component largely remains to be investigated. Our data show that certain types of bacteria are significantly associated with denture health and disease. Furthermore, the bacterial communities residing on the teeth and dentures of the same person are similar to each other independently of the surface, and thus, denture health could impact the maintenance of remaining teeth and vice versa.

Funder

UCLA School of Dentistry

HHS | NIH | National Institute of General Medical Sciences

HHS | NIH | National Institute of Dental and Craniofacial Research

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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