A Transferable IncC-IncX3 Hybrid Plasmid Cocarrying bla NDM-4 , tet (X), and tmexCD3-toprJ3 Confers Resistance to Carbapenem and Tigecycline-Reference-Cited by-同舟云学术

A Transferable IncC-IncX3 Hybrid Plasmid Cocarrying bla NDM-4 , tet (X), and tmexCD3-toprJ3 Confers Resistance to Carbapenem and Tigecycline

Published:2021-08-25 Issue:4 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Hirabayashi Aki¹,Dao Trung Duc²,Takemura Taichiro²,Hasebe Futoshi²,Trang Le Thi³,Thanh Nguyen Ha³,Tran Hoang Huy³,Shibayama Keigo⁴,Kasuga Ikuro⁵⁶,Suzuki Masato¹^ORCID

Affiliation:

1. Antimicrobial Resistance Research Center, National Institute of Infectious Diseases, Tokyo, Japan

2. Vietnam Research Station, Center for Infectious Disease Research in Asia and Africa, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan

3. National Institute of Hygiene and Epidemiology, Hanoi, Vietnam

4. Nagoya University Graduate School of Medicine, Nagoya, Japan

5. Vietnam-Japan University, Vietnam National University, Hanoi, Vietnam

6. Department of Urban Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan

Abstract

Tigecycline is important as a last-resort antimicrobial and effective against antimicrobial-resistant bacteria, such as carbapenem-producing Enterobacterales (CPE), whose infections are difficult to treat with antimicrobials. Since 2019, mobile tigecycline resistance genes, tet (X) and tmexCD-toprJ , and their variants have been reported mainly from China, and it has become important to understand their epidemiological situation and detailed genetic mechanisms.

Funder

Japan Agency for Medical Research and Development

MEXT | Japan Society for the Promotion of Science

National Foundation for Science and Technology Development

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00592-21

Reference21 articles.

1. Current perspectives on tigecycline resistance in Enterobacteriaceae: susceptibility testing issues and mechanisms of resistance