Glucan Unmasking Identifies Regulators of Temperature-Induced Translatome Reprogramming in C. neoformans-Reference-Cited by-同舟云学术

Glucan Unmasking Identifies Regulators of Temperature-Induced Translatome Reprogramming in C. neoformans

Published:2021-02-24 Issue:1 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Bloom Amanda L. M.¹,Goich David¹,Knowles Corey M.¹,Panepinto John C.¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Witebsky Center for Microbial Pathogenesis and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, New York, USA

Abstract

Cryptococcus neoformans is a fungal pathogen that causes devastating morbidity and mortality in immunocompromised individuals. It possesses several virulence factors that aid in its evasion from the host immune system, including a large polysaccharide capsule that cloaks the antigenic cell wall.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.01281-20

Reference33 articles.

1. Risk factors for cryptococcal infection among patients with rheumatoid arthritis receiving different immunosuppressive medications

2. Uncoupling of mRNA synthesis and degradation impairs adaptation to host temperature inCryptococcus neoformans

3. Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming