The Avian Retroviral Receptor Tva Mediates the Uptake of Transcobalamin Bound Vitamin B 12 (Cobalamin)-Reference-Cited by-同舟云学术

The Avian Retroviral Receptor Tva Mediates the Uptake of Transcobalamin Bound Vitamin B 12 (Cobalamin)

Published:2021-03-25 Issue:8 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Krchlíková Veronika¹,Mikešová Jana²,Geryk Josef¹,Bařinka Cyril²,Nexo Ebba³,Fedosov Sergey N.⁴,Kosla Jan¹,Kučerová Dana¹,Reinišová Markéta¹,Hejnar Jiří¹,Elleder Daniel¹^ORCID

Affiliation:

1. Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic

2. Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Vestec, Czech Republic

3. Department of Clinical Medicine/Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark

4. Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark

Abstract

We demonstrate that the ASLV receptor Tva participates in the physiological uptake of TC-Cbl because the viral infection suppresses the uptake of Cbl and vice versa. Our results pave the road for future studies addressing the following issues: (i) whether a virus infection can be inhibited by TC-Cbl complexes in vivo , and (ii) whether any human virus employs the human TC-Cbl receptor CD320.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02136-20

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