Affiliation:
1. Department of Medical Microbiology and Immunology1 and
2. Department of Dermatology,2 School of Medicine, University of California, Davis, California 95616
Abstract
ABSTRACT
The formaldehyde-killed, whole-spherule vaccine, which is protective against lethal challenge of laboratory animals with
Coccidioides immitis
, was fractionated. It yielded a soluble, multicomponent, subcellular fraction termed the 27K vaccine. This vaccine, when it was accompanied by adjuvant, protected mice against lethal intranasal and intravenous challenge with
C. immitis.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
59 articles.
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