Pharmacokinetics and Efficacy of the Benzothiazinone BTZ-043 against Tuberculous Mycobacteria inside Granulomas in the Guinea Pig Model-Reference-Cited by-同舟云学术

Pharmacokinetics and Efficacy of the Benzothiazinone BTZ-043 against Tuberculous Mycobacteria inside Granulomas in the Guinea Pig Model

Published:2023-04-18 Issue:4 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Eckhardt Emmelie¹,Li Yan²,Mamerow Svenja³,Schinköthe Jan⁴,Sehl-Ewert Julia¹,Dreisbach Julia⁵⁶,Corleis Björn¹,Dorhoi Anca¹,Teifke Jens¹,Menge Christian³,Kloss Florian²,Bastian Max¹^ORCID

Affiliation:

1. Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald, Germany

2. Transfer Group Anti-infectives, Leibniz Institute for Natural Product Research and Infection Biology, Leibniz-HKI, Jena, Germany

3. Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Jena, Germany

4. Institute of Veterinary Pathology, Faculty of Veterinary Medicine, Leipzig University, Leipzig, Germany

5. Division of Infectious Diseases and Tropical Medicine, University Hospital of the University of Munich (LMU), Munich, Germany

6. German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany

Abstract

Tuberculosis (TB), caused by Mycobacterium tuberculosis , is the world’s leading cause of mortality from a single bacterial pathogen. With increasing frequency, emergence of drug-resistant mycobacteria leads to failures of standard TB treatment regimens.

Funder

Bundesministerium für Bildung und Forschung

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01438-22

Reference38 articles.

1. World Health Organization. 2021. Global tuberculosis report 2021. World Health Organization, Geneva, Switzerland.

2. Preclinical testing of new drugs for tuberculosis: current challenges

3. Tackling Drug-Resistant Tuberculosis: Current Trends and Approaches

4. Extensively drug-resistant tuberculosis: epidemiology and management

5. World Health Organization. 2020. Global tuberculosis report 2020. World Health Organization, Geneva, Switzerland.

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