Therapeutic Effect and Mechanisms of the Novel Monosulfactam 0073-Reference-Cited by-同舟云学术

Therapeutic Effect and Mechanisms of the Novel Monosulfactam 0073

Published:2020-09-21 Issue:10 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Sun Ying¹,Liao Xueyuan¹,Huang Zhigang²,Xie Yaliu³,Liu Yanbin⁴,Ma Cuicui¹,Jiang Boguang¹,Zhang Li¹,Yan Yuhang⁵,Li Guobo⁵,Cheng Xingjun¹,Yin Qi¹,Ding Charles Z.²,Shen Liang²,Li Jian²,Chen Shuhui²,Wei Yuquan¹,Wang Zhenling¹^ORCID,Wei Xiawei⁶

Affiliation:

1. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China

2. WuXi AppTec Co. Ltd., Shanghai, China

3. Department of Otolaryngology, The Seventh People’s Hospital of Chengdu, Chengdu, China

4. Infectious Diseases Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China

5. Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, China

6. Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China

Abstract

This study aimed to evaluate the antimicrobial activity of the novel monosulfactam 0073 against multidrug-resistant Gram-negative bacteria in vitro and in vivo and to characterize the mechanisms underlying 0073 activity. The in vitro activities of 0073, aztreonam, and the combination with avibactam were assessed by MIC and time-kill assays. The safety of 0073 was evaluated using 3-(4,5-dimethylthizol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and acute toxicity assays.

Funder

Ministry of Science and Technology of the People's Republic of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00529-20

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