Affiliation:
1. División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica, San Luis Potosí, San Luis Potosí 78216, México
Abstract
ABSTRACT
We characterized the oxidative stress response of
Candida glabrata
to better understand the virulence of this fungal pathogen.
C. glabrata
could withstand higher concentrations of H
2
O
2
than
Saccharomyces cerevisiae
and even
Candida albicans
. Stationary-phase cells were extremely resistant to oxidative stress, and this resistance was dependent on the concerted roles of stress-related transcription factors Yap1p, Skn7p, and Msn4p. We showed that growing cells of
C. glabrata
were able to adapt to high levels of H
2
O
2
and that this adaptive response was dependent on Yap1p and Skn7p and partially on the general stress transcription factors Msn2p and Msn4p.
C. glabrata
has a single catalase gene,
CTA1
, which was absolutely required for resistance to H
2
O
2
in vitro. However, in a mouse model of systemic infection, a strain lacking
CTA1
showed no effect on virulence.
Publisher
American Society for Microbiology
Subject
Molecular Biology,General Medicine,Microbiology
Cited by
146 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献