Isolation of a possible archetypal JC virus DNA sequence from nonimmunocompromised individuals

Author:

Yogo Y1,Kitamura T1,Sugimoto C1,Ueki T1,Aso Y1,Hara K1,Taguchi F1

Affiliation:

1. Department of Viral Infection, University of Tokyo, Japan.

Abstract

We molecularly cloned JC polyomavirus DNAs from urine samples of eight nonimmunosuppressed patients and two healthy individuals. The cloned viral DNAs all contained an archetypal regulatory sequence from which various regulatory sequences of JC polyomavirus isolates derived from patients with progressive multifocal leukoencephalopathy could have evolved by deletion and amplification.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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