Acquired Flucytosine Resistance during Combination Therapy with Caspofungin and Flucytosine for Candida glabrata Cystitis-Reference-Cited by-同舟云学术

Acquired Flucytosine Resistance during Combination Therapy with Caspofungin and Flucytosine for Candida glabrata Cystitis

Published:2016-01 Issue:1 Volume:60 Page:662-665
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Charlier Caroline¹,El Sissy Carine²,Bachelier-Bassi Sophie³,Scemla Anne⁴,Quesne Gilles²,Sitterlé Emilie²,Legendre Christophe⁴,Lortholary Olivier¹,Bougnoux Marie-Elisabeth²³

Affiliation:

1. Université Paris Descartes Sorbonne Paris Cité, Service de Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker-Pasteur, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Institut Imagine, Paris, France

2. Université Paris Descartes Sorbonne Paris Cité, Service de Microbiologie Clinique, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France

3. Unité Biologie et Pathogénicité Fongiques, INRA, USC2019, Institut Pasteur, Paris, France

4. Université Paris Descartes Sorbonne Paris Cité, Service de Transplantation Rénale, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France

Abstract

ABSTRACT Treatment of Candida glabrata cystitis remains a therapeutic challenge, and an antifungal combination using flucytosine is one option. We describe two patients with refractory C. glabrata cystitis who failed flucytosine combined with caspofungin with early-acquired high-level resistance to flucytosine due to nonsense mutations in the FUR1 gene. Rapidly acquired flucytosine resistance with microbiological failure should discourage combination of caspofungin and flucytosine during urinary candidiasis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02265-15

Reference14 articles.

1. Candida Urinary Tract Infections—Treatment

2. Echinocandin antifungal drugs

3. ESCMID guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients;Cornely OA;Clin Microbiol Infect,2012

4. Caspofungin in the Treatment of Symptomatic Candiduria

5. Mutational Analysis of Flucytosine Resistance in Candida glabrata

Cited by 19 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Advancements in nanoparticle-based therapies for multidrug-resistant candidiasis infections: a comprehensive review;Nanotechnology;2024-05-30

2. Cross-feeding affects the target of resistance evolution to an antifungal drug;PLOS Genetics;2023-10-19

3. Cross-feeding affects the target of resistance evolution to an antifungal drug;2023-05-03

4. Antifungal Combinations against Candida Species: From Bench to Bedside;Journal of Fungi;2022-10-13

5. Candida auris Pan-Drug-Resistant to Four Classes of Antifungal Agents;Antimicrobial Agents and Chemotherapy;2022-07-19