Identification of Proteins Phosphorylated Directly by the Us3 Protein Kinase Encoded by Herpes Simplex Virus 1-Reference-Cited by-同舟云学术

Identification of Proteins Phosphorylated Directly by the Us3 Protein Kinase Encoded by Herpes Simplex Virus 1

Published:2005-07 Issue:14 Volume:79 Page:9325-9331
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Kato Akihisa¹,Yamamoto Mayuko¹,Ohno Takashi¹,Kodaira Hiroshi²,Nishiyama Yukihiro¹,Kawaguchi Yasushi¹³

Affiliation:

1. Department of Virology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya 466-8550

2. Development Planning and Coordination, Pharmaceutical Department, Yakult Honsha Co., LTD., Chuo-ku, Tokyo 104-0061

3. PRESTO, Japan Science and Technology Agency, Kawaguchi, Saitama, 332-0012, Japan

Abstract

ABSTRACT We have developed a system to analyze the specific protein kinase activity of herpes simplex virus 1 Us3 in vitro and shown that Us3 directly phosphorylates viral proteins UL34, ICP22, and Us9 and the cellular protein Bad, previously reported to be putative substrates. Using this system, we determined the phosphorylation sites of UL34 and identified UL31 as a previously unreported, novel substrate of Us3. This system will be useful for further identification of Us3 substrates and their phosphorylation sites, clarification of the role of Us3 in viral replication, and identification of additional Us3 function(s).

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.79.14.9325-9331.2005

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