TEM-184, a Novel TEM-Derived Extended-Spectrum β-Lactamase with Enhanced Activity against Aztreonam-Reference-Cited by-同舟云学术

TEM-184, a Novel TEM-Derived Extended-Spectrum β-Lactamase with Enhanced Activity against Aztreonam

Published:2018-09 Issue:9 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Piccirilli Alessandra¹,Perilli Mariagrazia¹,Amicosante Gianfranco¹,Conte Viola²,Tascini Carlo³,Rossolini Gian Maria⁴⁵,Giani Tommaso⁴^ORCID

Affiliation:

1. Dipartimento di Scienze Cliniche Applicate e Biotecnologiche, Università degli Studi dell'Aquila, L'Aquila, Italy

2. Dipartimento di Biotecnologie Mediche, Università degli Studi di Siena, Siena, Italy

3. Department of Infectious Diseases, Cotugno Hospital, Naples, Italy

4. Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, Florence, Italy

5. SOD Microbiologia e Virologia, Azienda Ospedaliera Universitaria Careggi, Florence, Italy

Abstract

TEM-184, a novel TEM-derived extended-spectrum β-lactamase (ESBL), was isolated from an Escherichia coli ST354 clinical strain. Compared to TEM-1, TEM-184 contains the mutations Q6K, E104K, I127V, R164S, and M182T.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00688-18

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