The Nonmonotonic Dose Dependence of Protein Expression in Cells Transfected with Self-Amplifying RNA-Reference-Cited by-同舟云学术

The Nonmonotonic Dose Dependence of Protein Expression in Cells Transfected with Self-Amplifying RNA

Published:2022-04-13 Issue:7 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Tanimoto Cheylene R.¹^ORCID,Thurm Abby R.¹,Brandt Devin S.¹,Knobler Charles M.¹,Gelbart William M.¹²³^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California, USA

2. Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California, USA

3. California NanoSystems Institute, University of California, Los Angeles, Los Angeles, California, USA

Abstract

Positive-sense RNA viruses often have a cytotoxic effect on their host cell because of the strength of their RNA replicase proteins, even though only one copy of their genome begins the viral life cycle in each cell. Noninfectious forms of them—replicons—which include just their RNA replication-related genes, are also strongly self-amplifying and cytotoxic.

Funder

National Science Foundation

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01858-21

Reference25 articles.

1. Self-Replicating RNA

2. The Limitless Future of RNA Therapeutics

3. Networks controlling mRNA decay in the immune system

4. Delivery of self-amplifying RNA vaccines in in vitro reconstituted virus-like particles

5. Rapid Evolution of Virus Sequences in Intrinsically Disordered Protein Regions

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. In Vivo Delivery of Spherical and Cylindrical In Vitro Reconstituted Virus-like Particles Containing the Same Self-Amplifying mRNA;Molecular Pharmaceutics;2024-05-06