High Circulating Frequencies of Tumor Necrosis Factor Alpha- and Interleukin-2-Secreting Human T-Lymphotropic Virus Type 1 (HTLV-1)-Specific CD4 + T Cells in Patients with HTLV-1-Associated Neurological Disease-Reference-Cited by-同舟云学术

High Circulating Frequencies of Tumor Necrosis Factor Alpha- and Interleukin-2-Secreting Human T-Lymphotropic Virus Type 1 (HTLV-1)-Specific CD4 + T Cells in Patients with HTLV-1-Associated Neurological Disease

Published:2003-09 Issue:17 Volume:77 Page:9716-9722
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Goon Peter K. C.¹,Igakura Tadahiko¹,Hanon Emmanuel¹,Mosley Angelina J.¹,Asquith Becca¹,Gould Keith G.¹,Taylor Graham P.²,Weber Jonathan N.²,Bangham Charles R. M.¹

Affiliation:

1. Department of Immunology

2. Genito-Urinary Medicine and Communicable Diseases, Imperial College London, London W2 1PG, United Kingdom

Abstract

ABSTRACT Significantly higher frequencies of tumor necrosis factor alpha- and interleukin-2-secreting human T-lymphotropic virus type 1 (HTLV-1)-specific CD4 + T cells were present in the peripheral blood mononuclear cells of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients than in those of asymptomatic carriers with similar provirus loads. The data suggest that HTLV-1-specific CD4 + T cells play a role in the pathogenesis of HAM/TSP.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.77.17.9716-9722.2003

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