Enhanced Immune Response After Immunosuppression by Streptococcal Pyrogenic Exotoxin

Author:

Hanna Edgar E.1,Watson Dennis W.2

Affiliation:

1. Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20014

2. Department of Microbiology, The Medical School, University of Minnesota, Minneapolis, Minnesota 55455

Abstract

Streptococcal pyrogenic exotoxin (SPE) was shown previously to be a potent immunosuppressant. This paper presents data documenting that immunosuppression frequently was followed by elevated antibody and plaque-forming cell levels as noted in our earlier report. The data are interpreted as a differential effect of SPE upon suppressor T cells and secreting B cells.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference9 articles.

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2. Thymus-marrow cell combinations. Synergism in antibody production;Claman H. N.;Proc. Soc. Exp. Biol. Med.,1966

3. Enhancement of antibody formation by whole body X-radiation;Dixon F. J.;J. Exp. Med.,1963

4. Host-parasite relationships among group A streptococci. IV. Suppression of antibody response by streptococcal pyrogenic exotoxin;Hanna E. E.;J. Bacteriol.,1968

5. A purified group A streptococcal pyrogenic exotoxin. Physiochemical and biological properties including the enhancement of susceptibility to endotoxin lethal shock;Kim Y. B.;J. Exp. Med.,1970

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