Efficacy of Nitazoxanide against Clinical Isolates of Mycobacterium tuberculosis

Abstract

ABSTRACTNitazoxanide (NTZ) has bactericidal activity against theH37Rvlaboratory strain ofMycobacterium tuberculosiswith a MIC of 16 μg/ml. However, its efficacy against clinical isolates ofM. tuberculosishas not been determined. We found that NTZ's MIC against 50 clinical isolates ranged from 12 to 28 μg/ml with a median of 16 μg/ml and was unaffected by resistance to first- or second-line antituberculosis drugs or a diversity of spoligotypes.