Affiliation:
1. Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA
Abstract
The zoonotic pathogen
Pasteurella multocida
produces a 146-kDa modular toxin (PMT) that enters host cells and manipulates intracellular signaling through action on its Gα protein targets. The N terminus of PMT (PMT-N) mediates cellular uptake through receptor-mediated endocytosis, followed by the delivery of the C-terminal catalytic domain from acidic endosomes into the cytosol.
Funder
HHS | NIH | National Institute of Allergy and Infectious Diseases
HHS | National Institutes of Health
UofI | University of Illinois at Urbana-Champaign
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
11 articles.
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